Dissolving polymer microneedle patches for influenza vaccination
نویسندگان
چکیده
منابع مشابه
Microneedle patches: usability and acceptability for self-vaccination against influenza.
While therapeutic drugs are routinely self-administered by patients, there is little precedent for self-vaccination. Convenient self-vaccination may expand vaccination coverage and reduce administration costs. Microneedle patches are in development for many vaccines, but no reports exist on usability or acceptability. We hypothesized that naïve patients could apply patches and that self-adminis...
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The prevalence of iron deficiency anemia (IDA) is predominant in women and children especially in developing countries. The disorder affects cognitive functions and physical activity. Although oral iron supplementation and parenteral therapy remains the preferred choice of treatment, gastric side effects and risk of iron overload decreases adherence to therapy. Transdermal route is an establish...
متن کاملDissolving Microneedle Patch for Rabies DNA Vaccination in Dogs
J. Arya , Y-W. Chen , K. Dewitt , Y-W. Chiang , M. R. Prausnitz 1 1 Georgia Institute of Technology, 2 Merial Ltd. Purpose To stabilize rabies DNA vaccine in a dissolving microneedle patch and evaluate immunogenicity and dose sparing in dogs. Rabies is mainly a disease of animals, whereas humans get rabies primarily when they are bitten by dogs. Vaccinating domestic dogs and other animals has r...
متن کاملDevelopment of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery
Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the dissolving MNs release the loaded vaccine antigen into the skin. To shorten skin application time for ...
متن کاملDissolving microneedle vaccine delivery systems
It iswell-established that the transdermal route is an attractive alternative for minimally-invasive drug delivery. The potential of the skin as a site for vaccine delivery has been demonstrated over the past decade, with research indicating stronger immune responses and improved duration of immunity compared with conventional intramuscular administration. Benefits of this minimally invasive va...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2010
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2182